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Circulating annexin A5 levels are associated with carotid intima-media thickness but not coronary plaque composition.
- Source :
-
Diabetes & vascular disease research [Diab Vasc Dis Res] 2017 Sep; Vol. 14 (5), pp. 415-422. Date of Electronic Publication: 2017 Jun 07. - Publication Year :
- 2017
-
Abstract
- Background: Annexin A5 (anxA5) is involved in processes which are crucial in atherogenesis. However, anxA5's relationship with atherosclerotic lesion extension and plaque composition in high-risk patients with type 2 diabetes remains unclear. Thus, we characterized the association between circulating anxA5 levels with atherosclerotic burden and coronary plaque composition in diabetes mellitus patients.<br />Methods: Intima-media thickness was determined in 96 diabetes mellitus patients with stable coronary artery disease. Furthermore, intracoronary optical coherence tomography was performed in 106 lesions to determine plaque composition.<br />Results: AnxA5 plasma levels of patients with intima-media thickening were higher (3.49 ± 2.19 ng/mL) compared to patients with normal intima-media thickness (2.24 ± 1.67 ng/mL, p = 0.002). Furthermore, anxA5 was associated with intima-media thickening on univariable [odds ratio = 1.445 (1.106-1.889), p = 0.007] and multivariable [odds ratio = 1.643 (1.166-2.314), p = 0.005] logistic regression analysis when adjusted for multiple cardiovascular risk factors and biomarkers. Furthermore, receiver operating characteristic analysis demonstrated that anxA5 predicted intima-media thickening with low-moderate diagnostic efficiency [area under the curve = 0.700 (0.592-0.808)]. In contrast, there was no association between anxA5 levels and coronary plaque composition as assessed by optical coherence tomography including the presence of lipid, calcified, fibrous plaque or the minimal thickness of the fibrous cap overlying the necrotic lipid core ( p = ns).<br />Conclusion: Circulating anxA5 levels are associated with carotid intima-media thickness but not coronary plaque composition in high-risk patients with diabetes mellitus.
- Subjects :
- Aged
Biomarkers blood
Case-Control Studies
Diabetes Mellitus, Type 2 diagnosis
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Predictive Value of Tests
Risk Factors
Up-Regulation
Annexin A5 blood
Carotid Artery Diseases blood
Carotid Artery Diseases diagnostic imaging
Carotid Intima-Media Thickness
Coronary Artery Disease blood
Coronary Artery Disease diagnostic imaging
Diabetes Mellitus, Type 2 blood
Plaque, Atherosclerotic
Tomography, Optical Coherence
Subjects
Details
- Language :
- English
- ISSN :
- 1752-8984
- Volume :
- 14
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Diabetes & vascular disease research
- Publication Type :
- Academic Journal
- Accession number :
- 28592134
- Full Text :
- https://doi.org/10.1177/1479164117710392