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Biocompatible Iron Phthalocyanine-Albumin Assemblies as Photoacoustic and Thermal Theranostics in Living Mice.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2017 Jun 28; Vol. 9 (25), pp. 21124-21132. Date of Electronic Publication: 2017 Jun 15. - Publication Year :
- 2017
-
Abstract
- Exploring novel and versatile nanomaterials for the construction of personalized multifunctional phototheranostics with significant potentials in bioimaging-guided tumor phototherapies has attracted considerable attention. Herein, the phototheranostic agent human serum albumin-iron (II) phthalocyanine FePc nanoparticles (HSA-FePc NPs) were fabricated for photoacoustic (PA) imaging-guided photothermal therapy (PTT) of cancer in vivo. The prepared HSA-FePc NPs exhibited high stability, efficient NIR absorption, good capability and stability of photothermal behavior with a high photothermal conversion efficiency of ∼44.4%, high contrast and spatial resolution of PA imaging, efficient cancer therapy, and low long-term toxicity. This potent multifunctional phototheranostic is, therefore, very promising and favorable for effective, precise, and safe antitumor treatment in clinical application.
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 9
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 28590721
- Full Text :
- https://doi.org/10.1021/acsami.7b04360