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Evaluation on subcellular partitioning and biodynamics of pulse copper toxicity in tilapia reveals impacts of a major environmental disturbance.

Evaluation on subcellular partitioning and biodynamics of pulse copper toxicity in tilapia reveals impacts of a major environmental disturbance.

Authors :
Ju YR
Yang YF
Tsai JW
Cheng YH
Chen WY
Liao CM
Source :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2017 Jul; Vol. 24 (21), pp. 17407-17417. Date of Electronic Publication: 2017 Jun 06.
Publication Year :
2017

Abstract

Fluctuation exposure of trace metal copper (Cu) is ubiquitous in aquatic environments. The purpose of this study was to investigate the impacts of chronically pulsed exposure on biodynamics and subcellular partitioning of Cu in freshwater tilapia (Oreochromis mossambicus). Long-term 28-day pulsed Cu exposure experiments were performed to explore subcellular partitioning and toxicokinetics/toxicodynamics of Cu in tilapia. Subcellular partitioning linking with a metal influx scheme was used to estimate detoxification and elimination rates. A biotic ligand model-based damage assessment model was used to take into account environmental effects and biological mechanisms of Cu toxicity. We demonstrated that the probability causing 50% of susceptibility risk in response to pulse Cu exposure in generic Taiwan aquaculture ponds was ~33% of Cu in adverse physiologically associated, metabolically active pool, implicating no significant susceptibility risk for tilapia. We suggest that our integrated ecotoxicological models linking chronic exposure measurements with subcellular partitioning can facilitate a risk assessment framework that provides a predictive tool for preventive susceptibility reduction strategies for freshwater fish exposed to pulse metal stressors.

Details

Language :
English
ISSN :
1614-7499
Volume :
24
Issue :
21
Database :
MEDLINE
Journal :
Environmental science and pollution research international
Publication Type :
Academic Journal
Accession number :
28589284
Full Text :
https://doi.org/10.1007/s11356-017-9421-7