Back to Search
Start Over
Development of a topical mupirocin spray for antibacterial and wound-healing applications.
- Source :
-
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2017 Oct; Vol. 43 (10), pp. 1715-1728. Date of Electronic Publication: 2017 Jun 18. - Publication Year :
- 2017
-
Abstract
- Objective: The aim of this study was to develop mupirocin topical spray using Eudragit E100 as a film-forming agent for the treatment of bacterial skin infections as well as to promote wound healing.<br />Materials and Methods: Twenty-seven of mupirocin formulations were formulated containing Eudragit E100 and other excipients. Mupirocin spray was prepared by aerosol crimping and filling machine using HFA-134a as a propellant. The formulations were evaluated for their stability and physicochemical properties. The factorial study was applied to evaluate the effects of glycerol and PEG400 on mupirocin-loaded Eudragit E100 films. The optimized formulation was assessed of drug release, antibacterial activities and in vitro cell line studies in comparison to the ointment formulation.<br />Results and Discussion: Mupirocin sprays were formulated and optimized to obtain the formulation with excellent physicochemical and mechanical properties of the dressing film. The formulation had an excellent stability up to a year with more than 80% of mupirocin content. Mupirocin was released from the film up to 90% within 2 h. The formulation had a potent antibacterial effect against S. aureus and S. epidermidis. The formulation was safe to use as a topical formulation that had no toxicity to keratinocytes, fibroblasts and monocytes. The formulation also had an antiendotoxin effect without stimulating the production of NO and inflammatory cytokines (IL-1β and TNF-α).<br />Conclusions: Mupirocin topical spray was successful developed as a topical formulation and can be used instead of the ointment formulation. Animal experiments are warranted to further emphasize the safe use in the human skin.
- Subjects :
- Administration, Topical
Animals
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Chemistry, Pharmaceutical
Humans
Mupirocin administration & dosage
Mupirocin chemistry
Staphylococcus aureus chemistry
Staphylococcus epidermidis chemistry
Tumor Necrosis Factor-alpha chemistry
Wound Healing physiology
Anti-Bacterial Agents administration & dosage
Hydrocarbons, Fluorinated chemistry
Mupirocin pharmacology
Staphylococcus aureus drug effects
Staphylococcus epidermidis drug effects
Tumor Necrosis Factor-alpha pharmacology
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5762
- Volume :
- 43
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Drug development and industrial pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 28581830
- Full Text :
- https://doi.org/10.1080/03639045.2017.1339077