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The regulation of corticosteroid receptors in response to chronic social defeat.
- Source :
-
Neurochemistry international [Neurochem Int] 2017 Sep; Vol. 108, pp. 397-409. Date of Electronic Publication: 2017 May 31. - Publication Year :
- 2017
-
Abstract
- Our previous studies demonstrated that chronic social defeat (CSD) up-regulated expression of the serotonin transporter (SERT) and norepinephrine transporter (NET) in the brain, which was mediated by corticosteroid receptors. In the present study we first analyzed the alterations of corticosteroid receptors in different brain regions after the CSD paradigm. The results showed that CSD significantly reduced glucocorticoid receptor (GR) protein levels in the CA1 and dentate gyrus of the hippocampus, as well as in central and basolateral nuclei of the amygdala, which was accompanied by the translocation of GR from cytoplasm to nuclei. CSD also markedly reduced GR mRNA levels and MR immunoreactivity in the CA1, CA3 and dentate gyrus areas of the hippocampus. Conversely, CSD pronouncedly enhanced GR mRNA and protein levels in the dorsal raphe nucleus and locus coeruleus relative to the control. As an extension of our previous studies, in situ hybridization and immunohistochemical staining demonstrated that CSD regimen caused a notable increase of SERT mRNA levels in the dorsal raphe nucleus and increased SERT immunoreactivities in CA1 and CA3 of the hippocampus, as well as those in the basolateral nuclei of the amygdala. Likewise, CSD regimen resulted in an evident enhancement of NET immunoreactivity in the CA1 of the hippocampus and in the basolateral nuclei of the amygdala. Our current findings suggest that GR expressional alterations in response to CSD are complex and brain region-specific, which may correspond to their different functions in these regions.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Amygdala chemistry
Animals
Chronic Disease
Female
Hippocampus chemistry
Male
Norepinephrine Plasma Membrane Transport Proteins analysis
Norepinephrine Plasma Membrane Transport Proteins metabolism
Rats
Rats, Long-Evans
Receptors, Glucocorticoid analysis
Receptors, Steroid analysis
Receptors, Steroid physiology
Serotonin Plasma Membrane Transport Proteins analysis
Serotonin Plasma Membrane Transport Proteins metabolism
Stress, Psychological psychology
Amygdala metabolism
Hippocampus metabolism
Receptors, Glucocorticoid physiology
Stress, Psychological metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9754
- Volume :
- 108
- Database :
- MEDLINE
- Journal :
- Neurochemistry international
- Publication Type :
- Academic Journal
- Accession number :
- 28577990
- Full Text :
- https://doi.org/10.1016/j.neuint.2017.05.021