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Neurodevelopmental outcome of isolated ventriculomegaly: a prospective cohort study.
- Source :
-
Prenatal diagnosis [Prenat Diagn] 2017 Aug; Vol. 37 (8), pp. 764-768. Date of Electronic Publication: 2017 Jun 23. - Publication Year :
- 2017
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Abstract
- Objective: Data regarding the neurodevelopmental outcome of children diagnosed in utero with isolated ventriculomegaly (IVM) are limited and principally founded on ultrasound-based studies. Here, we endeavored to assess the outcome of such cases in a large-scale, magnetic resonance imaging (MRI)-based study.<br />Methods: We conducted a study on 133 cases of IVM with a documented fetal brain MRI scan. Children were assessed at ages 18 to 36 months by using the Vineland Adaptive Behavior Scales (VABS).<br />Results: Vineland Adaptive Behavior Scales scores were within normal range. There was no significant difference between VABS score in symmetric versus asymmetric IVM (101.7 vs. 101.6, respectively; p = 0.94), and the VABS score of mild IVM was comparable with that of moderate IVM (101.8 vs. 101; p = 0.8). Only five cases (3.8%) were found to have an abnormal score (<85). There was no significant difference in the rate of abnormal scores between mild and moderate IVM (2.8% vs. 8.3%, respectively; p = 0.22).<br />Conclusion: In cases of isolated ventriculomegaly, a normal neurodevelopmental outcome is to be expected; moreover, the outcome does not appear to be affected by the severity or asymmetry of the ventriculomegaly. Thus, following a meticulous workup, patients can be given reassuring counseling regarding the child's prognosis. © 2017 John Wiley & Sons, Ltd.<br /> (© 2017 John Wiley & Sons, Ltd.)
Details
- Language :
- English
- ISSN :
- 1097-0223
- Volume :
- 37
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Prenatal diagnosis
- Publication Type :
- Academic Journal
- Accession number :
- 28568219
- Full Text :
- https://doi.org/10.1002/pd.5078