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Breast Cancer in the Central Nervous System: Multidisciplinary Considerations and Management.
- Source :
-
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting [Am Soc Clin Oncol Educ Book] 2017; Vol. 37, pp. 45-56. - Publication Year :
- 2017
-
Abstract
- Breast cancer is the second most common primary tumor associated with central nervous system (CNS) metastases. Patients with metastatic HER2-positive or triple-negative (estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, HER2-negative) breast cancer are at the highest risk of developing parenchymal brain metastases. Leptomeningeal disease is less frequent but is distributed across breast cancer subtypes, including lobular breast cancer. Initial treatment strategies can include surgery, radiation, intravenous or intrathecal chemotherapy, and/or targeted approaches. In this article, we review the epidemiology of breast cancer brain metastases, differences in clinical behavior and natural history by tumor subtype, and important considerations in the multidisciplinary treatment of these patients. We will highlight new findings that impact current standards of care, clinical controversies, and notable investigational approaches in clinical testing.
- Subjects :
- Brain Neoplasms epidemiology
Brain Neoplasms genetics
Brain Neoplasms secondary
Brain Neoplasms therapy
Central Nervous System Neoplasms epidemiology
Central Nervous System Neoplasms genetics
Central Nervous System Neoplasms secondary
Estrogen Receptor alpha genetics
Female
Humans
Meningeal Neoplasms epidemiology
Meningeal Neoplasms genetics
Meningeal Neoplasms secondary
Neoplasm Metastasis
Receptor, ErbB-2 genetics
Receptors, Progesterone genetics
Triple Negative Breast Neoplasms epidemiology
Triple Negative Breast Neoplasms genetics
Central Nervous System pathology
Central Nervous System Neoplasms therapy
Meningeal Neoplasms therapy
Triple Negative Breast Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1548-8756
- Volume :
- 37
- Database :
- MEDLINE
- Journal :
- American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
- Publication Type :
- Academic Journal
- Accession number :
- 28561683
- Full Text :
- https://doi.org/10.14694/EDBK_175338