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Mitochondria link metabolism and epigenetics in haematopoiesis.

Authors :
Schell JC
Rutter J
Source :
Nature cell biology [Nat Cell Biol] 2017 May 31; Vol. 19 (6), pp. 589-591.
Publication Year :
2017

Abstract

Due to their varied metabolic and signalling roles, mitochondria are important in mediating cell behaviour. By altering mitochondrial function, two studies now identify metabolite-induced epigenetic changes that have profound effects on haematopoietic stem cell fate and function.

Subjects

Subjects :
Animals
Hematopoietic Stem Cells metabolism
Humans
Models, Biological
Epigenesis, Genetic
Hematopoiesis genetics
Mitochondria metabolism

Details

Language :
English
ISSN :
1476-4679
Volume :
19
Issue :
6
Database :
MEDLINE
Journal :
Nature cell biology
Publication Type :
Academic Journal
Accession number :
28561053
Full Text :
https://doi.org/10.1038/ncb3540
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