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Activity of synthetic peptides against Chlamydia.
- Source :
-
Biopolymers [Biopolymers] 2017 Nov; Vol. 108 (6). - Publication Year :
- 2017
-
Abstract
- The in vitro activity of six synthetic peptides against 36 strains of Chlamydia from different origins was investigated. Clavanin MO (CMO) proved to be the most active peptide, reducing the inclusion number of all Chlamydia strains from eight different species tested by ≥50% at 10 µg mL <superscript>-1</superscript> . Mastoparan L showed an equal activity against C. trachomatis, C. pneumoniae, C. suis, and C. muridarum, but did not exert any inhibitory effect against C. psittaci, C. pecorum, C. abortus, and C. avium even at 80 µg mL <superscript>-1</superscript> . These data suggest that CMO could be a promising compound in the prevention and treatment of chlamydial infections.<br /> (© 2017 Wiley Periodicals, Inc.)
- Subjects :
- Amino Acid Sequence
Chlamydia drug effects
Intercellular Signaling Peptides and Proteins
Microscopy, Electron, Transmission
Peptides chemistry
Peptides pharmacology
Wasp Venoms chemical synthesis
Wasp Venoms chemistry
Wasp Venoms metabolism
Wasp Venoms pharmacology
Peptides chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0282
- Volume :
- 108
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biopolymers
- Publication Type :
- Academic Journal
- Accession number :
- 28555934
- Full Text :
- https://doi.org/10.1002/bip.23032