Functionalised collagen spheres reduce H 2 O 2 mediated apoptosis by scavenging overexpressed ROS.

Authors :: Tapeinos C
Larrañaga A
Sarasua JR
Pandit A
Source :: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2018 Oct; Vol. 14 (7), pp. 2397-2405. Date of Electronic Publication: 2017 May 26.
Publication Year :: 2018
Abstract: Excess reactive oxygen species (ROS) has been implicated in numerous diseases including cancer, cardiovascular and neurodegenerative diseases. Overexpression of ROS can lead to oxidative stress and subsequently to H <subscript>2</subscript> O <subscript>2</subscript> -mediated cell apoptosis. In this study, it was demonstrated that biodegradable PLGA microspheres coated with collagen type I and decorated with MnO <subscript>2</subscript> nanoparticles acted as ROS scavengers controlling the H <subscript>2</subscript> O <subscript>2</subscript> -mediated apoptosis of cells undergoing oxidative stress. The results showed that the functionalized collagen spheres can protect cells even under very harsh conditions of oxidative stress.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)

Subjects :: Animals
Cell Proliferation drug effects
Cells, Cultured
Humans
MCF-7 Cells
Rats
Apoptosis drug effects
Collagen chemistry
Hydrogen Peroxide pharmacology
Oxidants pharmacology
Oxidative Stress drug effects
Reactive Oxygen Species metabolism

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