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The emerging role of interleukin-37 in cardiovascular diseases.
- Source :
-
Immunity, inflammation and disease [Immun Inflamm Dis] 2017 Sep; Vol. 5 (3), pp. 373-379. Date of Electronic Publication: 2017 May 26. - Publication Year :
- 2017
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Abstract
- Introduction: Interleukin (IL)-37 is a newly identified member of the IL-1 family, and shows a growing role in a variety of diseases. This review aims at summarizing and discussing the role of IL-37 in cardiovascular diseases.<br />Methods: Data for this review were identified by searches of MEDLINE, Embase, and PubMed using appropriate search terms.<br />Results: IL-37 is a newly identified cytokine belonging to the IL-1 family and is expressed in inflammatory immune cells and several parenchymal cells. It has potent anti-inflammatory and immunosuppressive properties, with two mechanisms underlying this function. IL-37 is produced as a precursor and then cleaved into mature form in the cytoplasm by caspase-1, translocating to nucleus and suppressing the transcription of several pro-inflammatory genes by binding SMAD-3. Besides, IL-37 can be secreted extracellularly, and binds to IL-18Ra chain and recruits Toll/IL-1R (TIR)-8 for transducing anti-inflammatory signaling. IL-37 is upregulated in an inducible manner and negatively regulates signaling mediated by TLR agonists and pro-inflammatory cytokines. The cytokine has been shown to inhibit both innate and adaptive immunological responses, exert antitumor effects, and act as a prognostic marker in a variety of autoimmune diseases.<br />Conclusions: Recent studies have suggested that IL-37 plays a role in cardiovascular diseases. In this review, we provide an overview of the cytokine biology, discuss recent advances made in unraveling its cardio-protective effects, and suggest guidelines for future research.<br /> (© 2017 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 2050-4527
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Immunity, inflammation and disease
- Publication Type :
- Academic Journal
- Accession number :
- 28548248
- Full Text :
- https://doi.org/10.1002/iid3.159