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Therapeutic T cell engineering.
- Source :
-
Nature [Nature] 2017 May 24; Vol. 545 (7655), pp. 423-431. - Publication Year :
- 2017
-
Abstract
- Genetically engineered T cells are powerful new medicines, offering hope for curative responses in patients with cancer. Chimaeric antigen receptors (CARs) are a class of synthetic receptors that reprogram lymphocyte specificity and function. CARs targeting CD19 have demonstrated remarkable potency in B cell malignancies. Engineered T cells are applicable in principle to many cancers, pending further progress to identify suitable target antigens, overcome immunosuppressive tumour microenvironments, reduce toxicities, and prevent antigen escape. Advances in the selection of optimal T cells, genetic engineering, and cell manufacturing are poised to broaden T-cell-based therapies and foster new applications in infectious diseases and autoimmunity.
- Subjects :
- Animals
Antigens, CD19 immunology
Antigens, CD19 metabolism
Autoimmune Diseases immunology
Autoimmune Diseases pathology
Autoimmune Diseases therapy
Humans
Infections immunology
Infections pathology
Infections therapy
Neoplasms pathology
Receptors, Antigen, T-Cell immunology
Receptors, Antigen, T-Cell metabolism
Recombinant Fusion Proteins immunology
Recombinant Fusion Proteins metabolism
T-Lymphocytes immunology
Tumor Microenvironment
Cell Engineering methods
Neoplasms immunology
Neoplasms therapy
T-Lymphocytes metabolism
T-Lymphocytes transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 545
- Issue :
- 7655
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 28541315
- Full Text :
- https://doi.org/10.1038/nature22395