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Combinatorial Biosynthesis of (+)-Daurichromenic Acid and Its Halogenated Analogue.
- Source :
-
Organic letters [Org Lett] 2017 Jun 16; Vol. 19 (12), pp. 3183-3186. Date of Electronic Publication: 2017 May 25. - Publication Year :
- 2017
-
Abstract
- Daurichromenic acid is a meroterpenoid with various pharmacological activities that is biosynthesized from grifolic acid in Rhododendron dauricum. Heterologous expression of grifolic acid synthases from Stachybotrys bisbyi and a daurichromenic acid synthase from R. dauricum in Aspergillus oryzae mediated three-step combinatorial biosynthesis of (+)-daurichromenic acid through enantioselective 6-endo-trig cyclization. Additional introduction of a halogenase from Fusarium sp. into the strain resulted in the biosynthesis of (+)-5-chlorodaurichromenic acid, which exceeds the antibacterial activity of the original compounds.
- Subjects :
- Cyclization
Molecular Structure
Rhododendron
Chromans chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 19
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 28541042
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b01288