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The association between ghrelin levels and markers of arterial stiffness and inflammatory markers in Saudi subjects with metabolic syndrome.
- Source :
-
Diabetes & metabolic syndrome [Diabetes Metab Syndr] 2017 Dec; Vol. 11 Suppl 2, pp. S721-S725. Date of Electronic Publication: 2017 May 12. - Publication Year :
- 2017
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Abstract
- Background: Arterial stiffness is a principal cardiovascular risk factor. Metabolic syndrome (MetS) is a predisposing factor to arterial stiffness and persistent MetS circumstances can deteriorate the arterial stiffness severity. Low concentrations of plasma ghrelin are meticulously connected to arterial stiffness. This work targeted to judge the relationship between plasma ghrelin levels and intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) as markers of arterial stiffness and inflammatory markers and in Saudi subjects with MetS.<br />Patients and Methods: Eighty-four young adults were recruited from the visitors of the outpatient clinics of Taif hospitals, and then they were divided into a control group that involves subjects without MetS and a study group involving those with MetS. Anthropometric measurements, blood pressure, plasma ghrelin levels, fasting plasma glucose levels (FPG) and lipid profile were assessed. baPWV was measured by a volume plethysmograph while IMT was evaluated by ultrasonography.<br />Results: Plasma ghrelin values were significantly (P<0.001) decreased in the MetS group versus control group. Arterial stiffness was noticed in MetS group by significantly (P<0.01) increased IMT and baPWV (P<0.001) matched with control group. Plasma ghrelin concentrations were negatively associated with age, smoking, FPG, HbA1c, CRP, TNF-alpha, baPWV, and Lt Carotid IMT.<br />Conclusions: Depending on our outcomes showing the valuable properties of ghrelin in the cardiovascular system in patients with metabolic syndrome, it can be postulated that ghrelin may be associated with markers of atherosclerosis.<br /> (Copyright © 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Ankle Brachial Index
Atherosclerosis blood
Atherosclerosis etiology
Carotid Intima-Media Thickness
Case-Control Studies
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Pulse Wave Analysis
Atherosclerosis diagnosis
Biomarkers blood
Ghrelin blood
Inflammation Mediators metabolism
Metabolic Syndrome complications
Vascular Stiffness
Subjects
Details
- Language :
- English
- ISSN :
- 1878-0334
- Volume :
- 11 Suppl 2
- Database :
- MEDLINE
- Journal :
- Diabetes & metabolic syndrome
- Publication Type :
- Academic Journal
- Accession number :
- 28539201
- Full Text :
- https://doi.org/10.1016/j.dsx.2017.05.005