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Efficacy of Intratympanic Gentamicin in Menière's Disease With and Without Migraine.
- Source :
-
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology [Otol Neurotol] 2017 Aug; Vol. 38 (7), pp. 1005-1009. - Publication Year :
- 2017
-
Abstract
- Objective: To compare the efficacy of intratympanic gentamicin injection (ITG) on vertigo control, drop attacks, and functional level in Menière's disease patients with and without a history of migraine.<br />Patients: Menière's disease patients (patients with migraine and age- and sex-matched control patients without migraine) treated from 2002 to 2012 who failed medical management and received ITG, with a minimum 2-year follow up.<br />Intervention: ITG.<br />Main Outcome Measures: Vertigo control, drop attack prevalence, and change in functional level.<br />Results: Twenty-eight Menière's disease patients were included in this study (14 with migraine and 14 matched patients without migraine). There were three men and 11 women in each groups, with a mean age of 53 ± 8.9 years. Baseline characteristics (Menière's stage, vertigo frequency, drop attack prevalence, and functional level) before ITG were not significantly different between the two groups. Two years after ITG, 71% of Menière's disease with migraine patients and 78% of Menière's disease without migraine patients had class A, B, or C vertigo control (p > 0.999). Change in prevalence of drop attacks (43-7% versus 50-0%, respectively) was also similar (p > 0.999). However, significantly fewer vertigo control class A, B, and C migraine patients achieved functional level 1 or 2 (40%) compared with non-migraine patients (91%) (p = 0.007).<br />Conclusions: Although ITG appears equally effective in treating vertigo and drop attacks in Menière's disease with and without migraine, patients with migraine derive significantly less benefit in terms of functional improvement.
- Subjects :
- Adult
Aged
Anti-Bacterial Agents administration & dosage
Female
Gentamicins administration & dosage
Humans
Male
Meniere Disease complications
Middle Aged
Migraine Disorders complications
Syncope complications
Treatment Outcome
Vertigo complications
Anti-Bacterial Agents therapeutic use
Gentamicins therapeutic use
Meniere Disease drug therapy
Migraine Disorders drug therapy
Syncope drug therapy
Tympanic Membrane drug effects
Vertigo drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1537-4505
- Volume :
- 38
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
- Publication Type :
- Academic Journal
- Accession number :
- 28538472
- Full Text :
- https://doi.org/10.1097/MAO.0000000000001460