Back to Search
Start Over
Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2017 May 19; Vol. 22 (5). Date of Electronic Publication: 2017 May 19. - Publication Year :
- 2017
-
Abstract
- Three new abietane-type diterpenoids, named callicapoic acid M3 ( 1 ), callicapoic acid M4 ( 2 ) and callicapoic acid M5 ( 3 ), were isolated from the Callicarpa macrophylla Vahl. Their structures were established by spectroscopic techniques (IR, UV, MS, 1D and 2D NMR). All the isolated three compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1 , 2 and 3 showed potent inhibitory activity, with inhibition rates of 34.47-40.13%.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Abietanes isolation & purification
Abietanes pharmacology
Animals
Anti-Inflammatory Agents isolation & purification
Anti-Inflammatory Agents pharmacology
Cell Line
Lipopolysaccharides antagonists & inhibitors
Lipopolysaccharides pharmacology
Macrophages cytology
Macrophages metabolism
Magnetic Resonance Spectroscopy
Mice
Nitric Oxide biosynthesis
Plant Extracts chemistry
Plant Leaves chemistry
Abietanes chemistry
Anti-Inflammatory Agents chemistry
Callicarpa chemistry
Macrophages drug effects
Nitric Oxide antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 28534843
- Full Text :
- https://doi.org/10.3390/molecules22050842