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Ultrasmall Magnetic CuFeSe 2 Ternary Nanocrystals for Multimodal Imaging Guided Photothermal Therapy of Cancer.
- Source :
-
ACS nano [ACS Nano] 2017 Jun 27; Vol. 11 (6), pp. 5633-5645. Date of Electronic Publication: 2017 May 25. - Publication Year :
- 2017
-
Abstract
- Nanoscale ternary chalcogenides have attracted intense research interest due to their wealth of tunable properties and diverse applications in energy and environmental and biomedical fields. In this article, ultrasmall magnetic CuFeSe <subscript>2</subscript> ternary nanocrystals (<5.0 nm) were fabricated in the presence of thiol-functionalized poly(methacrylic acid) by an environmentally friendly aqueous method under ambient conditions. The small band gap and the existence of intermediate bands lead to a broad NIR absorbance in the range of 500-1100 nm and high photothermal conversion efficiency (82%) of CuFeSe <subscript>2</subscript> nanocrystals. The resultant CuFeSe <subscript>2</subscript> nanocrystals show superparamagnetism and effective attenuation for X-rays. In addition, they also exhibit excellent water solubility, colloidal stability, biocompatibility, and multifunctional groups. These properties enable them to be an ideal nanotheranostic agent for multimodal imaging [e.g., photoacoustic imaging (PAI), magnetic resonance imaging (MRI), computed tomography (CT) imaging] guided photothermal therapy of cancer.
- Subjects :
- Animals
Cell Line, Tumor
Hyperthermia, Induced methods
Magnetic Resonance Imaging methods
Male
Mice, Inbred BALB C
Multimodal Imaging methods
Nanoparticles chemistry
Photoacoustic Techniques methods
Phototherapy
Selenium Compounds chemistry
Tomography, X-Ray Computed methods
Copper chemistry
Iron chemistry
Nanoparticles therapeutic use
Neoplasms diagnostic imaging
Neoplasms therapy
Selenium Compounds therapeutic use
Theranostic Nanomedicine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1936-086X
- Volume :
- 11
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- ACS nano
- Publication Type :
- Academic Journal
- Accession number :
- 28525715
- Full Text :
- https://doi.org/10.1021/acsnano.7b01032