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Asian approaches in the treatment of trophoblastic disease.
- Source :
-
Obstetrics and gynecology clinics of North America [Obstet Gynecol Clin North Am] 1988 Sep; Vol. 15 (3), pp. 545-64. - Publication Year :
- 1988
-
Abstract
- The cure of trophoblastic disease depends on early recognition and appropriate chemotherapy. In many areas in Asia, doctors face the problems of insufficient funds and poor patient compliance with follow-up. In such situations, the maximum returns for the minimum input would consist of: 1. Routine ultrasound diagnosis for irregular vaginal bleeding associated with amenorrhea; 2. In hydatidiform mole, hysterectomy for women above 40 and those who have completed their families; prostaglandin and suction curettage for evacuation; 3. Prophylactic methotrexate-folinic acid, or dactinomycin or 5-FU for high-risk cases; 4. Follow-up by the simplified regimen using hCG test kits; 5. Chemotherapy with hysterectomy for choriocarcinoma, whether localized in the uterus or metastatic: if the uterus is to be conserved, there must be a good reason; 6. Multiagent chemotherapy as first line in all high-risk cases; and 7. In view of the excellent results with 5-FU in China, investigation of this drug elsewhere, initially in metastatic mole.
Details
- Language :
- English
- ISSN :
- 0889-8545
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Obstetrics and gynecology clinics of North America
- Publication Type :
- Academic Journal
- Accession number :
- 2852334