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Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring.
- Source :
-
American journal of epidemiology [Am J Epidemiol] 2017 Sep 15; Vol. 186 (6), pp. 719-729. - Publication Year :
- 2017
-
Abstract
- Nutrients that regulate methylation processes may modify susceptibility to the effects of air pollutants. Data from the National Birth Defects Prevention Study (United States, 1997-2006) were used to estimate associations between maternal exposure to nitrogen dioxide (NO2), dietary intake of methyl nutrients, and the odds of congenital heart defects in offspring. NO2 concentrations, a marker of traffic-related air pollution, averaged across postconception weeks 2-8, were assigned to 6,160 nondiabetic mothers of cases and controls using inverse distance-squared weighting of air monitors within 50 km of maternal residences. Intakes of choline, folate, methionine, and vitamins B6 and B12 were assessed using a food frequency questionnaire. Hierarchical regression models, which accounted for similarities across defects, were constructed, and relative excess risks due to interaction were calculated. Relative to women with the lowest NO2 exposure and high methionine intake, women with the highest NO2 exposure and lowest methionine intake had the greatest odds of offspring with a perimembranous ventricular septal defect (odds ratio = 3.23, 95% confidence interval: 1.74, 6.01; relative excess risk due to interaction = 2.15, 95% confidence interval: 0.39, 3.92). Considerable departure from additivity was not observed for other defects. These results provide modest evidence of interaction between nutrition and NO2 exposure during pregnancy.<br /> (© The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adult
Air Pollutants analysis
Air Pollution adverse effects
Air Pollution analysis
Case-Control Studies
Choline analysis
Diet Records
Female
Folic Acid analysis
Food Analysis
Humans
Infant, Newborn
Methionine analysis
Nitrogen Dioxide analysis
Odds Ratio
Pregnancy
Prenatal Nutritional Physiological Phenomena
Risk Factors
United States
Vitamin B 12 analysis
Vitamin B 6 analysis
Air Pollutants toxicity
Eating
Heart Defects, Congenital chemically induced
Maternal Exposure adverse effects
Nitrogen Dioxide toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1476-6256
- Volume :
- 186
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 28520847
- Full Text :
- https://doi.org/10.1093/aje/kwx139