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Regulation of cerebral arterial BKCa channels by angiotensin II signaling in adult offspring exposed to prenatal high sucrose diets.
- Source :
-
Bioscience reports [Biosci Rep] 2017 Jun 21; Vol. 37 (3). Date of Electronic Publication: 2017 Jun 21 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- Prenatal insults have been shown to affect vascular functions, leading to increased risks of cardiovascular diseases in offspring. The present study determined whether high sucrose (HS) intake in pregnancy affected central vascular functions in middle cerebral artery (MCA) of offspring. Sprague-Dawley rats were fed a standard food and tap water with normal or high (20%) sucrose content during pregnancy. Offspring were maintained with normal diets and tap water. Central vascular functions and related ion channels were assessed in male offspring at 5 months old. Compared with the control, angiotensin II (AII)-induced vasoconstrictions were significantly higher in the MCA of the offspring exposed to prenatal HS. In the MCA, large conductance Ca <superscript>2+</superscript> -activated K <superscript>+</superscript> channels (BKCa) currents were decreased with a reduction of opening frequency, sensitivity to intracellular Ca <superscript>2+</superscript> /membrane voltage, and BKβ1 expression. mRNA levels of AT1α and AT2, as well as AT1/AT2 ratio, were significantly increased in the MCA of offspring following exposure to prenatal HS diets. The data suggested that prenatal HS diets could alter microvascular activities in the MCA, probably via changes of BKCa channels in the brain.<br /> (© 2017 The Author(s).)
- Subjects :
- Analysis of Variance
Angiotensin II genetics
Animals
Calcium metabolism
Female
Glucose analysis
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits analysis
Male
Microvessels chemistry
Middle Cerebral Artery chemistry
Patch-Clamp Techniques
Potassium metabolism
Pregnancy
Rats
Rats, Sprague-Dawley
Receptors, Angiotensin genetics
Receptors, Angiotensin metabolism
Vasoconstriction
Angiotensin II metabolism
Brain blood supply
Diet adverse effects
Dietary Sucrose adverse effects
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits metabolism
Microvessels metabolism
Middle Cerebral Artery metabolism
Prenatal Exposure Delayed Effects metabolism
Vascular Diseases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4935
- Volume :
- 37
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioscience reports
- Publication Type :
- Academic Journal
- Accession number :
- 28515221
- Full Text :
- https://doi.org/10.1042/BSR20160624