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1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Jul 17; Vol. 56 (30), pp. 8865-8869. Date of Electronic Publication: 2017 Jun 19. - Publication Year :
- 2017
-
Abstract
- The 2-substituted piperidine core is found in drugs (18 FDA-approved drugs), however, their spirocyclic analogues remain unknown. Described here is the synthesis of spirocyclic analogues for 2-substituted piperidines and a demonstration of their validation in drug discovery.<br /> (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 56
- Issue :
- 30
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 28510279
- Full Text :
- https://doi.org/10.1002/anie.201703801