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Anti-influenza effect of the major flavonoids from Salvia plebeia R.Br. via inhibition of influenza H1N1 virus neuraminidase.
- Source :
-
Natural product research [Nat Prod Res] 2018 May; Vol. 32 (10), pp. 1224-1228. Date of Electronic Publication: 2017 May 15. - Publication Year :
- 2018
-
Abstract
- To determine the compounds responsible for its anti-influenza activities, we isolated the three flavonoids, 6-hydroxyluteolin 7-O-β-d-glucoside (1), nepitrin (2), homoplantaginin (3) from the MeOH extract of Salvia plebeia R.Br. and identified them by comparing the spectroscopic data with that reported in the literature. The contents of the three flavonoids in the whole extract were 108.74 ± 0.95, 46.26 ± 2.19, and 69.35 ± 1.22 mg/g for 6-hydroxyluteolin 7-O-β-d-glucoside, nepitrin, and homoplantaginin, respectively, which demonstrates that they are the major constituents of this plant. The three flavonoids were evaluated for their inhibitory activities against influenza virus H1N1 A/PR/9/34 neuraminidase and H1N1-induced cytopathic effect (CPE) on Madin-Darby canine kidney (MDCK) cells. Our results demonstrated the following arrangement for their anti-influenza activities: nepitrin (2) > 6-hydroxyluteolin 7-O-β-d-glucoside (1) > homoplantaginin (3). The potent inhibitory activities of these flavonoids against influenza suggested their potential to be developed as novel anti-influenza drugs in the future.
- Subjects :
- Animals
Antiviral Agents chemistry
Chromatography, High Pressure Liquid
Dogs
Drug Evaluation, Preclinical methods
Flavonoids analysis
Flavonoids chemistry
Glucosides analysis
Glucosides pharmacology
Luteolin analysis
Luteolin pharmacology
Madin Darby Canine Kidney Cells
Neuraminidase metabolism
Plant Extracts analysis
Plant Extracts chemistry
Reproducibility of Results
Viral Proteins metabolism
Antiviral Agents pharmacology
Flavonoids pharmacology
Influenza A Virus, H1N1 Subtype enzymology
Neuraminidase antagonists & inhibitors
Salvia chemistry
Viral Proteins antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 32
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 28504013
- Full Text :
- https://doi.org/10.1080/14786419.2017.1326042