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Evaluation of venous thrombosis and tissue factor in epithelial ovarian cancer.
- Source :
-
Gynecologic oncology [Gynecol Oncol] 2017 Jul; Vol. 146 (1), pp. 146-152. Date of Electronic Publication: 2017 May 10. - Publication Year :
- 2017
-
Abstract
- Objective: Ovarian clear cell carcinoma (OCCC) and high grade serous ovarian cancer (HGSOC) are associated with the highest risk of VTE among patients with epithelial ovarian cancer (EOC). Tissue factor (TF) is a transmembrane glycoprotein which can trigger thrombosis. We sought to evaluate if there is an association between VTE and tumor expression of tissue factor (TF), plasma TF, and microvesicle TF (MV TF) activity in this high-risk population.<br />Methods: We performed a case-control study of OCCC and HGSOC patients with and without VTE. 105 patients who underwent surgery at a tertiary care center between January 1995 and October 2013 were included. Plasma TF was measured with an enzyme-linked immunosorbent assay. A TF-dependent Factor Xa generation assay was used to measure MV TF activity. Immunohistochemical (IHC) analysis was performed to evaluate tumor expression of TF.<br />Results: 35 women with OCCC or HGSOC diagnosed with VTE within 9months of surgery were included in the case group. Those with VTE had a worse OS, p<0.0001, with a greater than three-fold increase in risk of death, HR 3.33 (CI 1.75-6.35). There was no significant difference in median plasma TF level or MV TF activity level between patients with and without VTE. OCCC patients had greater expression of TF in their tumors than patients with HGSOC, p<0.0001.<br />Conclusions: TFMV activity and plasma TF level were not predictive of VTE in this patient population. Given the extensive expression of TF in OCCC tumors, it is unlikely IHC expression will be useful in risk stratification for VTE in this population.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Ovarian Epithelial
Case-Control Studies
Enzyme Multiplied Immunoassay Technique
Female
Humans
Immunohistochemistry
Middle Aged
Neoplasm Staging
Survival Analysis
Thromboplastin biosynthesis
Neoplasms, Glandular and Epithelial blood
Neoplasms, Glandular and Epithelial pathology
Ovarian Neoplasms blood
Ovarian Neoplasms pathology
Thromboplastin metabolism
Venous Thrombosis blood
Venous Thrombosis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6859
- Volume :
- 146
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gynecologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 28501328
- Full Text :
- https://doi.org/10.1016/j.ygyno.2017.04.021