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Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies.
- Source :
-
Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2017 Jun 01; Vol. 76 (6), pp. 458-466. - Publication Year :
- 2017
-
Abstract
- Two population-based studies key to advancing knowledge of brain aging are the Honolulu-Asia Aging Study (HAAS) and the Nun Study. Harmonization of their neuropathologic data allows cross comparison, with findings common to both studies likely generalizable, while distinct observations may point to aging brain changes that are dependent on sex, ethnicity, environment, or lifestyle factors. Here, we expanded the neuropathologic evaluation of these 2 studies using revised NIA-Alzheimer's Association guidelines and compared directly the neuropathologic features of resistance and apparent cognitive resilience. There were significant differences in prevalence of Alzheimer disease neuropathologic change, small vessel vascular brain injury, and Lewy body disease between these 2 studies, suggesting that sex, ethnicity, and lifestyle factors may significantly influence resistance to developing brain injury with age. In contrast, hippocampal sclerosis prevalence was very similar, but skewed to poorer cognitive performance, suggesting that hippocampal sclerosis could act sequentially with other diseases to impair cognitive function. Strikingly, despite these observed differences, the proportion of individuals resistant to all 4 diseases of brain or displaying apparent cognitive resilience was virtually identical between HAAS and Nun Study participants. Future in vivo validation of these results awaits comprehensive biomarkers of these 4 brain diseases.<br /> (© 2017 American Association of Neuropathologists, Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Biomarkers
Cerebral Small Vessel Diseases pathology
Cohort Studies
Cost of Illness
Ethnicity
Female
Hawaii
Hippocampus pathology
Humans
Lewy Body Disease pathology
Life Style
Male
Sex Characteristics
Aging physiology
Aging psychology
Alzheimer Disease pathology
Alzheimer Disease psychology
Cognition
Nuns
Resilience, Psychological
Subjects
Details
- Language :
- English
- ISSN :
- 1554-6578
- Volume :
- 76
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of neuropathology and experimental neurology
- Publication Type :
- Academic Journal
- Accession number :
- 28499012
- Full Text :
- https://doi.org/10.1093/jnen/nlx030