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[Endogenous retroviral sequences in the human genome can play a physiological or pathological role].
- Source :
-
Medecine sciences : M/S [Med Sci (Paris)] 2017 Apr; Vol. 33 (4), pp. 397-403. Date of Electronic Publication: 2017 May 12. - Publication Year :
- 2017
-
Abstract
- Human endogenous retroviruses (HERV) represent a large part of our genome and the few elements that have retained a potential of expression still remain "dormant" in physiological conditions. In some instances, they can be awakened by environmental factors activating their expression. The best studied conditions of HERV activation are infections caused by microorganisms such as viruses of the Herpesvirus family. This activation can thus lead to the expression of pathogenic proteins such as envelope proteins belonging to the HERV-W and HERV-K families, respectively involved in Multiple Sclerosis (MS) and amyotrophic lateral sclerosis (ALS). Endogenous retroviral proteins can also acquire a physiological function beneficial for humans. This is the case of Syncytin-1 from the HERV-W family, that is involved in placenta formation.<br /> (© 2017 médecine/sciences – Inserm.)
- Subjects :
- Animals
Cytomegalovirus physiology
DNA Methylation
Endogenous Retroviruses genetics
Gene Expression Regulation, Viral
Herpesviridae pathogenicity
Herpesviridae physiology
Herpesviridae Infections genetics
Herpesviridae Infections pathology
Herpesviridae Infections virology
Herpesvirus 4, Human physiology
Humans
Viral Envelope Proteins genetics
Viral Envelope Proteins physiology
Endogenous Retroviruses pathogenicity
Endogenous Retroviruses physiology
Genome, Human genetics
Subjects
Details
- Language :
- French
- ISSN :
- 1958-5381
- Volume :
- 33
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Medecine sciences : M/S
- Publication Type :
- Academic Journal
- Accession number :
- 28497735
- Full Text :
- https://doi.org/10.1051/medsci/20173304009