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Transporters Involved in Metformin Pharmacokinetics and Treatment Response.
- Source :
-
Journal of pharmaceutical sciences [J Pharm Sci] 2017 Sep; Vol. 106 (9), pp. 2245-2250. Date of Electronic Publication: 2017 May 08. - Publication Year :
- 2017
-
Abstract
- Metformin, widely used as first-line treatment for type 2 diabetes, exists primarily as a hydrophilic cation at physiological pHs. As such, membrane transporters play a substantial role in its absorption, tissues distribution, and renal elimination. Multiple organic cation transporters are determinants of the pharmacokinetics of metformin, and many of them are important in its pharmacological action, as mediators of metformin entry into target tissues. Furthermore, a recent genome-wide association study in a large multi-ethnic population implicated polymorphisms in SLC2A2, encoding the glucose transporter, GLUT2, as important determinants of response to metformin. Here, we describe the key transporters associated with metformin pharmacokinetics and response.<br /> (Copyright © 2017. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1520-6017
- Volume :
- 106
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of pharmaceutical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28495567
- Full Text :
- https://doi.org/10.1016/j.xphs.2017.04.078