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HLA-C Single Nucleotide Polymorphism Associated with Increased Viral Load Level in HIV-1 Infected Individuals from Northeast Brazil.
- Source :
-
Current HIV research [Curr HIV Res] 2017; Vol. 15 (4), pp. 266-272. - Publication Year :
- 2017
-
Abstract
- Background: Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression.<br />Objective and Method: We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321) and ZNRD1-AS1 (rs3869068), single nucleotide polymorphisms (SNPs) in 266 HIV-1-infected and 223 unexposed-uninfected individuals from Northeast Brazil and their relation to HIV-1 infection, CD4 T cells count and viral load pre-treatment.<br />Results: HLA-C SNPs were in Linkage Disequilibrium (D'=0.84), constituting four possible haplotypes. Our results showed that HLA-C, ZNRD1 and ZNRD1-AS1 SNPs as well as HLA-C haplotypes frequencies were not significantly different between HIV-1-infected and unexposed-uninfected individuals. In addition, we analyzed HLA-C and ZNRD-1 and ZNRD1-AS1 SNPs considering CD4+ T cell counts and viral load before the antiretroviral treatment. Individuals carrying HLA-C rs9264942 TT genotype showed a significant increased level of HIV-1 viral load pre-treatment, in comparison with individuals carrying the CC genotype (p-value = 0.0092). Finally, we stratified our findings according to CCR5Δ32 allele presence along with the studied SNPs: no statistically significant influence over viral load pre-treatment has been found.<br />Conclusion: The association between HLA-C rs9264942 SNP and viral load prior treatment in an admixed population from North East Brazil was in agreement with findings from previous studies obtained on different ethnic groups; however more studies should be conducted in order to clarify how HLA-C impair the HIV-1 replication.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Subjects :
- Adolescent
Adult
Brazil
CD4 Lymphocyte Count
Female
HIV-1 isolation & purification
Humans
Male
Middle Aged
Young Adult
DNA-Binding Proteins genetics
HIV Infections genetics
HIV Infections virology
HLA-C Antigens genetics
Histocompatibility Antigens Class I genetics
Polymorphism, Single Nucleotide
Viral Load
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4251
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current HIV research
- Publication Type :
- Academic Journal
- Accession number :
- 28494720
- Full Text :
- https://doi.org/10.2174/1570162X15666170511141741