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Blastemal cells of nephroblastomatosis complex share an onco-developmental antigen with embryonic kidney and Wilms' tumor. An immunohistochemical study on polysialic acid distribution.
- Source :
-
The American journal of pathology [Am J Pathol] 1988 Dec; Vol. 133 (3), pp. 596-608. - Publication Year :
- 1988
-
Abstract
- Previous investigations on polysialic acid of the neural cell adhesion molecule NCAM in human kidney have demonstrated its presence during nephrogenesis in embryonic kidney, absence in normal adult kidney, and reexpression in Wilms' tumor. These data showed that polysialic acid of NCAM is an onco-developmental antigen in human kidney and provided more direct evidence for the metanephric origin of Wilms' tumor. In the present study, five cases of Wilms' tumor associated with nephroblastomatosis complexes were immunohistochemically investigated with a monoclonal antibody for the presence of polysialic acid. Regardless of the type of nephroblastomatosis complex, ie, renal nodular blastema, simple tubular metanephric hamartoma, sclerosing metanephric hamartoma with adenoma, or incipient Wilms' tumor, immunoreactivity for polysialic acid was found in the blastemal cells, but was undetectable in all other structural elements. Because only blastemal cells exhibited a characteristic feature of embryonal differentiating metanephric derivatives, it appears that Wilms' tumor has its origin not exclusively in nodular renal blastema but rather in blastemal cells present in the various forms of nephroblastomatosis complex. The presence of polysialic acid of NCAM in blastemal cells in such lesions indicates that further events in addition to the expression of the embryonic form of this cell adhesion molecule may be involved in the pathogenesis of Wilms' tumor.
- Subjects :
- Child, Preschool
Female
Hamartoma analysis
Hamartoma immunology
Hamartoma pathology
Humans
Immunohistochemistry
Infant
Kidney Neoplasms analysis
Kidney Neoplasms pathology
Male
Wilms Tumor analysis
Wilms Tumor pathology
Antigens, Neoplasm analysis
Kidney Neoplasms immunology
Polysaccharides analysis
Sialic Acids analysis
Wilms Tumor immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9440
- Volume :
- 133
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The American journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 2849302