Review: MicroRNAS in ocular surface and dry eye diseases.

Authors :: Rassi DM
De Paiva CS
Dias LC
Módulo CM
Adriano L
Fantucci MZ
Rocha EM
Source :: The ocular surface [Ocul Surf] 2017 Oct; Vol. 15 (4), pp. 660-669. Date of Electronic Publication: 2017 May 05.
Publication Year :: 2017
Abstract: Since the first description of microRNAs (miRNAs) in the 1990s, more than 60 papers have described the role of miRNAs on the ocular surface and lacrimal gland (LG). MicroRNAs (miRNAs) have a role in several physiological events and in mediation of disease. They inhibit gene expression by blocking messenger RNA. Diseases such as Sjögren syndrome (SS), ocular surface neoplasias, and infections are known to increase or reduce the expression of specific miRNAs. These miRNAs play key roles in modulating inflammation, delaying or enhancing wound healing, cell differentiation metabolism, and survival. This review describes the current understanding of miRNAs as biomarkers, mediators of diseases, and potential therapeutic targets in ocular surface diseases.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)