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The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2017 Jul; Vol. 31 (7), pp. 1115-1126. Date of Electronic Publication: 2017 Apr 21. - Publication Year :
- 2017
-
Abstract
- Aims: We aimed to assess whether vitamin D supplementation improves glucose metabolism in adults with type 2 diabetes.<br />Methods: PubMed and Cochrane database were searched up to July 1st 2016 for randomized controlled trials that assessed the relationship between vitamin D supplementation and glucose metabolism (change in hemoglobin A1C (HbA1C) and fasting blood glucose (FBG)) among adults with type 2 diabetes.<br />Results: Twenty nine trials (3324 participants) were included in the systematic review. Among 22 studies included in the meta-analysis, 19 reported HbA1C, 16 reported FBG outcomes and 15 were deemed poor quality. There was a modest reduction in HbA1C (-0.32% [-0.53 to -0.10], I <superscript>2</superscript> =91.9%) compared to placebo after vitamin D supplementation but no effect on FBG (-2.33mg/dl [-6.62 to 1.95], I <superscript>2</superscript> =59.2%). In studies achieving repletion of vitamin D deficiency (n=7), there were greater mean reductions in HbA1C (-0.45%, [-1.09 to 0.20]) and FBG (-7.64mg/dl [-16.25 to 0.97]) although not significant.<br />Conclusions: We found a modest reduction of HbA1C after vitamin D treatment in adults with type 2 diabetes albeit with substantial heterogeneity between studies and no difference in FBG. Larger studies are needed to further evaluate the glycemic effects of vitamin D treatment especially in patients with vitamin D deficiency.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Blood Glucose analysis
Combined Modality Therapy
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 metabolism
Glycated Hemoglobin analysis
Humans
Hypoglycemic Agents therapeutic use
Randomized Controlled Trials as Topic
Reproducibility of Results
Vitamin D analogs & derivatives
Vitamin D blood
Vitamin D Deficiency blood
Vitamin D Deficiency complications
Vitamin D Deficiency diet therapy
Diabetes Mellitus, Type 2 diet therapy
Dietary Supplements
Evidence-Based Medicine
Hyperglycemia prevention & control
Hypoglycemia prevention & control
Vitamin D therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1873-460X
- Volume :
- 31
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 28483335
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2017.04.019