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Risk factors associated with multi-drug-resistant Acinetobacter baumannii nosocomial infections at a tertiary care hospital in Makkah, Saudi Arabia - a matched case-control study.
- Source :
-
The Journal of international medical research [J Int Med Res] 2017 Jun; Vol. 45 (3), pp. 1181-1189. Date of Electronic Publication: 2017 May 08. - Publication Year :
- 2017
-
Abstract
- Objective To determine risk factors for multi-drug-resistant Acinetobacter baumannii (MDR-AB) nosocomial infections in intensive care units in a tertiary care hospital, Makkah, Saudi Arabia. Methods We performed a hospital-based, matched case-control study in patients who were admitted to Al Noor Specialist Hospital between 1 January 2012 and 31 August 2012. The study included cases of A. baumannii nosocomial infection and controls without infection. Controls were matched to cases by age and ward of admission. Results The most frequent site of infection was the respiratory tract (77.3%). Susceptibility to antimicrobial MDR-AB was 92.0% for ceftazidime and ciprofloxacin, while it was 83.3% for imipenem, 83.0% for trimethoprim, 79.0% for amikacin, and 72.7% for gentamicin. Multiple logistic regression of risk factors showed that immunosuppression (OR = 2.9; 95% CI 1.5-5.6; p = 0.002), clinical outcome (OR = 0.4; 95% CI 0.3-0.9; p = 0.01), invasive procedures (OR = 7.9; 95% CI 1.8-34.2; p = 0.002), a central venous catheter (OR = 2.9; 95% CI 1.5-5.6; p = 0.000), and an endotracheal tube (OR = 3.4; 95% CI 1.6-7.3; p = 0.001) were associated with MDR-AB. Conclusions Acinetobacter nosocomial infections are associated with admission to the ICU (Intensive care unit) and exposure to invasive procedures.
- Subjects :
- Acinetobacter baumannii isolation & purification
Adult
Aged
Case-Control Studies
Cross Infection microbiology
Female
Humans
Male
Middle Aged
Risk Factors
Saudi Arabia epidemiology
Acinetobacter baumannii drug effects
Cross Infection epidemiology
Tertiary Care Centers organization & administration
Subjects
Details
- Language :
- English
- ISSN :
- 1473-2300
- Volume :
- 45
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of international medical research
- Publication Type :
- Academic Journal
- Accession number :
- 28480813
- Full Text :
- https://doi.org/10.1177/0300060517706284