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Immunotherapy-induced sarcoidosis in patients with melanoma treated with PD-1 checkpoint inhibitors: Case series and immunophenotypic analysis.
- Source :
-
International journal of rheumatic diseases [Int J Rheum Dis] 2017 Sep; Vol. 20 (9), pp. 1277-1285. Date of Electronic Publication: 2017 May 08. - Publication Year :
- 2017
-
Abstract
- Aim: Sarcoidosis is a multisystem granulomatous disease. This condition has a documented association with the diagnosis of melanoma and can be induced in melanoma patients receiving anti-neoplastic therapy. We evaluated a case series of melanoma patients who developed immunotherapy-induced sarcoidosis.<br />Methods: Three patients with melanoma (n = 1 resected Stage III, n = 2 metastatic) treated with anti-programmed cell death (PD)-1 antibody therapy at two institutions developed biopsy-proven sarcoidosis. We used mass cytometry to determine expression of the relevant chemokine receptors (CR) by peripheral blood mononuclear cells for two of the three patients who developed sarcoidosis and 13 melanoma patients who did not. Blood samples were collected before receiving PD-1 checkpoint inhibitor therapy.<br />Results: Immunophenotypic analysis demonstrated abnormally high numbers of circulating Th17.1 (CCR6 <superscript>+</superscript> CCR4 <superscript>-</superscript> CXCR3 <superscript>+</superscript> CCR10 <superscript>-</superscript> ) cells prior to commencing PD-1 checkpoint inhibitor therapy in five of 15 melanoma patients, including both the patients who developed sarcoidosis during the course of therapy.<br />Conclusion: Our findings support prior literature implicating Th17.1 cells in the pathogenesis of sarcoidosis. However, we demonstrate these findings in patients with melanoma prior to administration of checkpoint therapy and before the onset of clinically symptomatic sarcoidosis. The identification of elevated Th17.1 cells in melanoma patients who have not developed sarcoidosis may reflect the established association between melanoma and sarcoidosis. With some patients receiving these agents over a prolonged period, the clinical course of immunotherapy-induced sarcoidosis is uncertain.<br /> (© 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adrenal Cortex Hormones therapeutic use
Adult
Aged
Biomarkers blood
Biopsy
Female
Humans
Male
Melanoma blood
Melanoma immunology
Melanoma secondary
Middle Aged
Neoplasm Staging
Phenotype
Positron-Emission Tomography
Predictive Value of Tests
Programmed Cell Death 1 Receptor immunology
Sarcoidosis, Pulmonary blood
Sarcoidosis, Pulmonary diagnosis
Sarcoidosis, Pulmonary drug therapy
Skin Neoplasms blood
Skin Neoplasms immunology
Skin Neoplasms pathology
Th17 Cells immunology
Th17 Cells metabolism
Tomography, X-Ray Computed
Treatment Outcome
Antineoplastic Agents, Immunological adverse effects
Immunophenotyping
Immunotherapy adverse effects
Melanoma drug therapy
Programmed Cell Death 1 Receptor antagonists & inhibitors
Sarcoidosis, Pulmonary chemically induced
Skin Neoplasms drug therapy
Th17 Cells drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1756-185X
- Volume :
- 20
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of rheumatic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 28480561
- Full Text :
- https://doi.org/10.1111/1756-185X.13076