Radiovaccination Hypothesis.

Authors :: Eapen L
Source :: Cureus [Cureus] 2017 Apr 04; Vol. 9 (4), pp. e1135. Date of Electronic Publication: 2017 Apr 04.
Publication Year :: 2017
Abstract: The details of patients who have entered remission from metastatic melanoma following palliative radiotherapy are reported. We review the relevant immune physiology and radiotherapy particulars and propose the hypothesis that radiovaccination with high fractional dose to skin metastases can stimulate the development of a robust systemic anti-tumoral immune response capable of causing remission of metastatic disease.<br />Competing Interests: The authors have declared that no competing interests exist.