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Neuropsychological long-term sequelae of Ebola virus disease survivors - A systematic review.

Authors :
Lötsch F
Schnyder J
Goorhuis A
Grobusch MP
Source :
Travel medicine and infectious disease [Travel Med Infect Dis] 2017 Jul - Aug; Vol. 18, pp. 18-23. Date of Electronic Publication: 2017 May 04.
Publication Year :
2017

Abstract

Background: The recent West African Ebola virus disease (EVD) outbreak had catastrophic impact on populations, health care systems and economies of the affected countries. Somatic symptoms have been reported to persist long beyond the acute infection. This review was conducted to provide an overview on neuro- and socio-psychological long-term sequelae of EVD survivors.<br />Methods: Utilizing Pubmed and PsycInfo databases, a systematic review prepared according to PRISMA guidelines. Only studies reporting quantitative data on neuropsychological sequelae three weeks or later after discharge from the Ebola-treating unit were included. Pooled proportions of common outcomes were calculated.<br />Results: In total, 224 papers were identified, of which 10 were included. Depression, insomnia, fatigue, anxiety and post-traumatic stress were common sequelae in EVD survivors. However, data from high-quality studies were scarce.<br />Conclusions: EVD survivors have been thought to commonly face neuropsychological long-term sequelae. Methodological drawbacks and heterogeneity of current studies limit conclusions of the impact and magnitude of such sequelae. We advocate the preparation of a prospective, controlled cohort study protocol in preparation for a future outbreak.<br /> (Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Details

Language :
English
ISSN :
1873-0442
Volume :
18
Database :
MEDLINE
Journal :
Travel medicine and infectious disease
Publication Type :
Academic Journal
Accession number :
28478336
Full Text :
https://doi.org/10.1016/j.tmaid.2017.05.001