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Usefulness of combining 123 I-FP-CIT-SPECT striatal asymmetry index and cardiac 123 I-metaiodobenzylguanidine scintigraphy examinations for diagnosis of parkinsonisms.
- Source :
-
Journal of the neurological sciences [J Neurol Sci] 2017 Jun 15; Vol. 377, pp. 174-178. Date of Electronic Publication: 2017 Apr 17. - Publication Year :
- 2017
-
Abstract
- Background: Although single-photon emission computerized tomography of the dopamine transporter (DAT-SPECT) is useful for diagnosing parkinsonian syndrome, its applicability toward the early phase of Parkinson's disease remains unknown.<br />Methods: We enrolled 32 patients showing parkinsonism with normal cardiac <superscript>123</superscript> I-metaiodobenzylguanidine (MIBG) uptake and abnormal DAT-SPECT findings among 84 consecutive patients with parkinsonism. We divided these patients into two groups (group 1: Parkinson's disease, group 2: corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy), and compared their clinical characteristics, specific binding ratios, and striatal asymmetry indexes on DAT-SPECT examinations.<br />Results: The striatal asymmetry indexes were significantly lower in group 1 than in group 2 (p<0.05), but there were no differences in the specific binding ratios between the two groups.<br />Conclusion: The combined use of striatal asymmetry index on DAT-SPECT and cardiac MIBG scintigraphy might offer useful clues for the differential diagnosis of the early phase Parkinson's disease from other parkinsonian syndromes.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Corpus Striatum drug effects
Dopamine Plasma Membrane Transport Proteins metabolism
Female
Humans
Iodine Radioisotopes pharmacokinetics
Male
Middle Aged
Parkinsonian Disorders pathology
Protein Binding drug effects
Retrospective Studies
Severity of Illness Index
3-Iodobenzylguanidine pharmacokinetics
Corpus Striatum diagnostic imaging
Myocardial Perfusion Imaging
Parkinsonian Disorders diagnostic imaging
Tomography, Emission-Computed, Single-Photon
Tropanes pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5883
- Volume :
- 377
- Database :
- MEDLINE
- Journal :
- Journal of the neurological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28477690
- Full Text :
- https://doi.org/10.1016/j.jns.2017.04.026