Uranium ( 238 U) bioaccumulation and its persuaded alterations on hematological, serological and histological parameters in freshwater fish Pangasius sutchi.

The early biomarkers for the hematological, serological and histological alterations due to the effect of ½ and ¼ LC ₅₀ of ²³⁸ U in different organs in freshwater fish Pangasius sutchi for water-borne ²³⁸ U accumulation was investigated. The toxicological data due to ²³⁸ U accumulation on the hematological parameters such as hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and hematocrit (Hct) to evaluate the oxygen carrying capacity has been indicated as the secondary response of the organisms. The biomarkers of liver damage were determined as by Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), Alkaline Phosphatase (ALP), γ-Glutamyl Transferase (γ-GT). Similarly, the renal biomarkers of kidney damage were accessed by creatinine, uric acid, triglycerides, and cholesterol. The decrease in hemoglobin in the experimental group due to disturbed synthesis of hemoglobin was directly proportional to the concentration and exposure duration of ²³⁸ U. The histological studies proved that liver and gills are the target organ for ²³⁸ U toxicity. The extensive histological lesions were observed in various tissues due to oxidative stress by the accumulation of ²³⁸ U, and the ²³⁸ U toxicity in the organs was in the order of Gills<liver<brain<muscle. This study can be useful indicators of ²³⁸ U toxicity to assess fish health in Uranium ( ²³⁸ U) biomonitoring programs.
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