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Utilizing Paper-Based Devices for Antimicrobial-Resistant Bacteria Detection.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Jun 06; Vol. 56 (24), pp. 6886-6890. Date of Electronic Publication: 2017 May 05. - Publication Year :
- 2017
-
Abstract
- Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents. Per the World Health Organization, AMR has an estimated annual cost of USD 34 billion in the US and is predicted to be the number one cause of death worldwide by 2050. One way AMR bacteria can spread, and by which individuals can contract AMR infections, is through contaminated water. Monitoring AMR bacteria in the environment currently requires that samples be transported to a central laboratory for slow and labor intensive tests. We have developed an inexpensive assay using paper-based analytical devices (PADs) that can test for the presence of β-lactamase-mediated resistance. To demonstrate viability, the PAD was used to detect β-lactam resistance in wastewater and sewage and identified resistance in individual bacterial species isolated from environmental water sources.<br /> (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Bacteria classification
Bacteria growth & development
Colony Count, Microbial
Colorimetry
Electrochemical Techniques
Microbiological Techniques
Reproducibility of Results
Sewage microbiology
Wastewater microbiology
Water Microbiology
Anti-Bacterial Agents pharmacology
Bacteria drug effects
Bacteria isolation & purification
Paper
beta-Lactam Resistance
beta-Lactamase Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 56
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 28474847
- Full Text :
- https://doi.org/10.1002/anie.201702776