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Iodine(III)-Catalyzed Formal [2 + 2 + 1] Cycloaddition Reaction for Metal-Free Construction of Oxazoles.
- Source :
-
Organic letters [Org Lett] 2017 May 19; Vol. 19 (10), pp. 2506-2509. Date of Electronic Publication: 2017 May 04. - Publication Year :
- 2017
-
Abstract
- The iodine(III) catalyst, in situ generated from iodoarene as a precatalyst with m-CPBA and Tf <subscript>2</subscript> NH, promoted the metal-free [2 + 2 + 1] cycloaddition-type reactions of alkynes, nitriles, and oxygen atoms for the regioselective formations of 2,4-disubstituted and 2,4,5-trisubstituted oxazole. A first example of iodine catalysis for multicomponent reactions is represented.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 19
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 28471179
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b00742