Palladium-Catalyzed Enantioselective Redox-Relay Heck Alkynylation of Alkenols To Access Propargylic Stereocenters.

Authors :: Chen ZM
Nervig CS
DeLuca RJ
Sigman MS
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Jun 01; Vol. 56 (23), pp. 6651-6654. Date of Electronic Publication: 2017 May 03.
Publication Year :: 2017
Abstract: An enantioselective redox-relay Heck alkynylation of di- and trisubstituted alkenols to construct propargylic stereocenters is disclosed using a new pyridine oxazoline ligand. This strategy allows direct access to chiral β-alkynyl carbonyl compounds employing allylic alcohol substrates in contrast to more traditional conjugate addition methods.<br /> (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Catalysis
Ligands
Oxazoles chemistry
Safrole chemistry
Stereoisomerism
Urea chemistry
Alkanes chemistry
Aniline Compounds chemistry
Indoles chemistry
Palladium chemistry
Safrole analogs & derivatives
Styrenes chemistry

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