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Diagnostic Practices for Suspected Community-Acquired Central Nervous System Infection in the Post-Conjugate Vaccine Era.
Diagnostic Practices for Suspected Community-Acquired Central Nervous System Infection in the Post-Conjugate Vaccine Era.
- Source :
-
Pediatric emergency care [Pediatr Emerg Care] 2019 Nov; Vol. 35 (11), pp. 774-776. - Publication Year :
- 2019
-
Abstract
- Objective: The aim of this study was to evaluate diagnostic practices for suspected community-acquired central nervous system (CNS) infection in an urban pediatric population.<br />Methods: This is an observational, retrospective single-center review of cerebrospinal fluid (CSF) studies in children, 1 month to 21 years old, evaluated for suspected CNS infection from 2004 to 2014. Cases of suspected nosocomial meningitis were excluded. The frequency of N-methyl-D-aspartate receptor antibody (NMDAR ab) encephalitis was analyzed from 2010 to 2014.<br />Results: A total of 940 unique patient visits with CSF studies were included in the final analysis. There were 940 bacterial cultures sent; 4 (0.42%) grew suspected CSF bacterial pathogens, and 18 (1.9%) grew organisms that were suspected contaminants. Bacterial pathogens included late-onset group B Streptococcus in 3 infants younger than 3 months and Streptococcus pneumoniae in an unvaccinated 9-year-old child. Viral CNS infection was 7.5 times more frequent than bacterial infection. Enterovirus was the only virus isolated. Five cases positive for NMDAR ab were identified since 2010.<br />Conclusions: Bacterial studies were performed more frequently than viral and other studies. Cerebrospinal fluid bacterial culture was nearly 5 times more likely to yield a contaminant than a pathogen. The frequency of viral infection was likely underestimated as only 20% were tested, mainly by culture, which is suboptimal. These data suggest diagnostic practices for the evaluation of suspected community-acquired CNS infections in children need to be modified to reflect current epidemiology and highlight the need for greater accessibility to polymerase chain reaction for viral diagnostics. Furthermore, NMDAR ab-mediated encephalitis should be considered early in children presenting with suggestive symptoms.
- Subjects :
- Adolescent
Adult
Bacterial Typing Techniques statistics & numerical data
Central Nervous System Bacterial Infections cerebrospinal fluid
Central Nervous System Viral Diseases cerebrospinal fluid
Child
Child, Preschool
Community-Acquired Infections etiology
Female
Humans
Infant
Male
Polymerase Chain Reaction statistics & numerical data
Retrospective Studies
Vaccination Coverage
Young Adult
Central Nervous System Bacterial Infections epidemiology
Central Nervous System Viral Diseases epidemiology
Community-Acquired Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1535-1815
- Volume :
- 35
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Pediatric emergency care
- Publication Type :
- Academic Journal
- Accession number :
- 28463942
- Full Text :
- https://doi.org/10.1097/PEC.0000000000001147