Back to Search
Start Over
Active and Passive Smoking and Risk of Nasopharyngeal Carcinoma: A Population-Based Case-Control Study in Southern China.
- Source :
-
American journal of epidemiology [Am J Epidemiol] 2017 Jun 15; Vol. 185 (12), pp. 1272-1280. - Publication Year :
- 2017
-
Abstract
- The magnitude and patterns of associations between smoking and risk of nasopharyngeal carcinoma (NPC) in high-incidence regions remain uncertain. Associations with active and passive tobacco smoking were estimated using multivariate logistic regression in a population-based case-control study of 2,530 NPC cases and 2,595 controls in Guangdong and Guangxi, southern China, in 2010-2014. Among men, risk of NPC was significantly higher in current smokers compared with never smokers (odds ratio (OR) = 1.32, 95% confidence interval (CI): 1.14, 1.53) but not in former smokers (OR = 0.92, 95% CI: 0.73, 1.17). Risk increased with smoking intensity (per 10 cigarettes/day, OR = 1.09, 95% CI: 1.03, 1.16), smoking duration (per 10 years, OR = 1.11, 95% CI: 1.06, 1.16), and cumulative smoking (per 10 pack-years, OR = 1.08, 95% CI: 1.04, 1.12). Risk decreased with later age at smoking initiation (per year, OR = 0.97, 95% CI: 0.96, 0.98) but not greater time since smoking cessation. Exposures to passive smoking during childhood (OR = 1.24, 95% CI: 1.03, 1.48) and from a spouse during adulthood (OR = 1.30, 95% CI: 1.03, 1.63) were independently associated with increased NPC risk in never-smoking men and women, but exposure-response trends were not observed. In conclusion, active and passive tobacco smoking are associated with modestly increased risk of NPC in southern China; risk is highest among long-term smokers.<br /> (© The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adult
Aged
Carcinoma epidemiology
Case-Control Studies
China epidemiology
Female
Humans
Incidence
Logistic Models
Male
Middle Aged
Multivariate Analysis
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms epidemiology
Odds Ratio
Risk Factors
Time Factors
Young Adult
Carcinoma etiology
Nasopharyngeal Neoplasms etiology
Smoking adverse effects
Tobacco Smoke Pollution adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1476-6256
- Volume :
- 185
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- American journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 28459936
- Full Text :
- https://doi.org/10.1093/aje/kwx018