Low-Intensity Pulsed Ultrasound-Induced Spinal Fusion is Coupled with Enhanced Calcitonin Gene-Related Peptide Expression in Rat Model.

Authors :: Zhou XY
Xu XM
Wu SY
Wang F
Zhang ZC
Yang YL
Li M
Wei XZ
Source :: Ultrasound in medicine & biology [Ultrasound Med Biol] 2017 Jul; Vol. 43 (7), pp. 1486-1493. Date of Electronic Publication: 2017 Apr 28.
Publication Year :: 2017
Abstract: Low-intensity pulsed ultrasound (LIPUS) has been found to accelerate fracture healing. In this study, we analyzed the role of calcitonin gene-related peptide (CGRP) in a rat spinal fusion model treated with LIPUS. The results revealed that LIPUS significantly increases bone formation, and the process was coupled with elevated CGRP innervation. CGRP was located in fibrous tissue, closely surrounding the allograft and newly formed cartilage. The density of CGRP peaked at week 3 after surgery in both the control (non-LIPUS-treated) and LIPUS-treated groups. These results suggest that LIPUS might accelerate spinal fusion by promoting sensory nerve fiber innervation.<br /> (Copyright © 2017 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.)

Subjects :: Animals
High-Energy Shock Waves therapeutic use
Lumbar Vertebrae radiation effects
Male
Rats
Rats, Sprague-Dawley
Treatment Outcome
Up-Regulation radiation effects
Calcitonin Gene-Related Peptide biosynthesis
Lumbar Vertebrae physiopathology
Lumbar Vertebrae surgery
Spinal Fusion methods
Ultrasonic Therapy methods
Ultrasonic Waves

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