Galectin-3 in acute coronary syndrome.

Authors :: Agnello L
Bivona G
Lo Sasso B
Scazzone C
Bazan V
Bellia C
Ciaccio M
Source :: Clinical biochemistry [Clin Biochem] 2017 Sep; Vol. 50 (13-14), pp. 797-803. Date of Electronic Publication: 2017 Apr 26.
Publication Year :: 2017
Abstract: Acute coronary syndrome (ACS) is a very common cause of hospitalizations worldwide each year. In the past decades biomarkers have become an indispensable tool for diagnosis, risk stratification and prognosis of cardiovascular disease, including ACS. Despite Troponin is considered the gold standard in diagnosis of ACS, several molecules have been investigated to identify predictive biomarkers of prognosis. Among these, Gal-3 has emerged as a promising prognostic marker. It has a pivotal role in inflammation and fibrosis. Both experimental and clinical studies have shown Gal-3 is an independent predictor of all-cause mortality, cardiovascular death and occurrence of HF following ACS. This article reviews the literature data regarding the role of Galectin-3 in ACS setting.<br /> (Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.)