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Association between vitamin D deficiency and health-related quality of life in patients with chronic kidney disease from the KNOW-CKD study.
- Source :
-
PloS one [PLoS One] 2017 Apr 27; Vol. 12 (4), pp. e0174282. Date of Electronic Publication: 2017 Apr 27 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- Vitamin D deficiency is a growing health problem in both the general population and in patients with chronic kidney disease (CKD). However, the relationship between serum 25-hydroxyvitamin D levels and health-related quality of life in CKD is not well established. This study examined the association between vitamin D deficiency and quality of life in pre-dialysis CKD patients. Serum 25-hydroxyvitamin D levels and the Korean version of the Kidney Disease Quality of Life short form were obtained for 1844 pre-dialysis CKD patients in the prospective KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD). The baseline estimated glomerular filtration rate was 50.26 ± 0.71 mL/min/1.73 m2. We identified 1294 (70.2%) patients with vitamin D deficiency, defined as a 25-hydroxyvitamin D level < 20 ng/ml. The scores of the kidney disease component summary, physical component summary, and mental component summary in the vitamin D deficiency group were significantly lower compared to the scores of those without vitamin D deficiency. The serum 25-hydroxyvitamin D level was independently associated with the kidney disease component summary and mental component summary scores (β = 0.147, p = 0.003 and β = 0.151, p = 0.047). In conclusion, there was a significant association between serum 25-hydroxyvitamin D levels and kidney disease component summary and mental component summary scores in pre-dialysis CKD patients.
- Subjects :
- Cohort Studies
Female
Glomerular Filtration Rate
Humans
Male
Middle Aged
Renal Insufficiency, Chronic blood
Renal Insufficiency, Chronic physiopathology
Republic of Korea epidemiology
Health
Quality of Life
Renal Insufficiency, Chronic complications
Renal Insufficiency, Chronic epidemiology
Vitamin D Deficiency complications
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 28448520
- Full Text :
- https://doi.org/10.1371/journal.pone.0174282