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Pretreatment late-phase DCE-MRI predicts outcome in locally advanced cervix cancer.
- Source :
-
Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2017 May; Vol. 56 (5), pp. 675-681. Date of Electronic Publication: 2017 Feb 28. - Publication Year :
- 2017
-
Abstract
- Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may provide prognostic biomarkers for cervix carcinoma. We have shown previously that the early phase of the signal intensity-versus-time curve (SITC) may have significant prognostic power. The purpose of the present investigation was to explore the prognostic value of the late phase of the SITC.<br />Material and Methods: DCE-MRI data of 80 patients (FIGO stage IB-IVA) treated with concurrent chemoradiotherapy were examined. Four parameters were calculated from the late-phase SITC: tumor volume with decreasing signal, tumor fraction with decreasing signal, tumor volume with increasing signal (TVIS), and tumor fraction with increasing signal.<br />Results: Multivariate analysis involving clinical parameters and late-phase SITC parameters suggested that TVIS is a strong independent prognostic factor for both disease-free and overall survival. When early-phase SITC parameters were included in the multivariate analysis, the early-phase SITC, but not the late-phase SITC, was found to have independent prognostic value.<br />Conclusion: The late-phase SITC can provide prognostic factors for the outcome of cervix carcinoma, that is, a large tumor volume with increasing late-phase SITCs is associated with poor outcome. However, the prognostic power of the late-phase SITC is not as strong as that of the early-phase SITC.
- Subjects :
- Female
Follow-Up Studies
Humans
Neoplasm Recurrence, Local diagnostic imaging
Neoplasm Recurrence, Local metabolism
Neoplasm Recurrence, Local pathology
Prognosis
Survival Rate
Tumor Burden
Uterine Cervical Neoplasms diagnostic imaging
Uterine Cervical Neoplasms metabolism
Uterine Cervical Neoplasms pathology
Chemoradiotherapy mortality
Contrast Media metabolism
Magnetic Resonance Imaging methods
Neoplasm Recurrence, Local mortality
Uterine Cervical Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1651-226X
- Volume :
- 56
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta oncologica (Stockholm, Sweden)
- Publication Type :
- Academic Journal
- Accession number :
- 28447564
- Full Text :
- https://doi.org/10.1080/0284186X.2017.1294762