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Immune Response Against Salmonella Enteritidis Is Unsettled by HIV Infection.

Authors :
Cacemiro MC
Espíndola MS
Galvão-Lima LJ
Soares LS
Fontanari C
Prata MA
Campioni F
Falcão JP
Bollela VR
Frantz FG
Source :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2018; Vol. 1057, pp. 29-39.
Publication Year :
2018

Abstract

The human immunodeficiency virus (HIV) is responsible for more than 2 million new infections per year and opportunistic infections such as Salmonella spp. Gastroenteritis is an important cause of mortality and morbidity in developing countries. Monocytes and macrophages play a critical role in the innate immune response against bacterial infections. However during HIV infection the virus can infect these cells and although they are more resistant to the cytopathic effects, they represent an important viral reservoir in these patients. Our aim was to evaluate the monocyte functions from HIV-1 infected patients after in vitro exposition to Salmonella Enteritidis. Our results suggest impairment of monocytes phagocytic and microbicidal activity in HIV-1 non-treated patients, which was more evident in women, if compared with men. Moreover, monocytes from HIV-1 infected and non-treated patients after stimulation with the bacteria, produced more pro-inflammatory cytokines than monocytes from HIV-treated patients, suggesting that HIV-1 infected patients have their functions unbalanced, once in the presence of an opportunistic infection in vitro.

Details

Language :
English
ISSN :
0065-2598
Volume :
1057
Database :
MEDLINE
Journal :
Advances in experimental medicine and biology
Publication Type :
Academic Journal
Accession number :
28447329
Full Text :
https://doi.org/10.1007/5584_2017_40