Back to Search
Start Over
Potential Use of Modulators of Oxidative Stress as Add-on Therapy in Patients with Anxiety Disorders.
- Source :
-
Current drug targets [Curr Drug Targets] 2018; Vol. 19 (6), pp. 636-650. - Publication Year :
- 2018
-
Abstract
- Background: It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders.<br />Objective: In this review, we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use.<br />Discussion and Conclusion: While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy between preclinical and clinical data, we encourage further studies aimed at better investigating the utility of the modulation of oxidative stress in humans, as an adjunctive therapy of the traditional integrated psychotherapeutic and pharmacological approach.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Subjects :
- Animals
Anti-Anxiety Agents administration & dosage
Anxiety Disorders physiopathology
Disease Models, Animal
Humans
Psychotherapy methods
Reactive Nitrogen Species metabolism
Reactive Oxygen Species metabolism
Anti-Anxiety Agents pharmacology
Anxiety Disorders drug therapy
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5592
- Volume :
- 19
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Current drug targets
- Publication Type :
- Academic Journal
- Accession number :
- 28443504
- Full Text :
- https://doi.org/10.2174/1389450118666170425153356