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Cocaine use is associated with a higher prevalence of elevated ST2 concentrations.
- Source :
-
Clinical biochemistry [Clin Biochem] 2017 Sep; Vol. 50 (13-14), pp. 791-793. Date of Electronic Publication: 2017 Apr 23. - Publication Year :
- 2017
-
Abstract
- Background: Cocaine is a well-known risk factor for acute cardiac events, but the effects in users outside of acute events are less clear. We investigated a possible association between cocaine use and the concentration of a novel biomarker for cardiac stress and heart failure, ST2.<br />Methods: A case-control study was conducted to compare ST2 concentrations by the presence of cocaine in patients presenting for care, but not cardiac care, at an urban safety net hospital.<br />Results: In samples taken from 100 cocaine-positive and 100 cocaine-negative patients, the presence of cocaine was associated with ST2 concentrations>35ng/mL. Serum concentrations of benzoylecgonine, a major cocaine metabolite, were significantly correlated with ST2 concentrations.<br />Conclusions: Cocaine use is associated with subclinical cardiac stress and damage outside of acute cardiac events. This information could add to better stratification of cocaine users with elevated ST2 concentrations who may be at higher risk for developing heart failure and other cardiac complications.<br /> (Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Biomarkers blood
Biomarkers urine
Biotransformation
Case-Control Studies
Cocaine analogs & derivatives
Cocaine blood
Cocaine urine
Cocaine-Related Disorders physiopathology
Cocaine-Related Disorders urine
Female
Heart Diseases chemically induced
Heart Diseases epidemiology
Heart Diseases metabolism
Hospitals, General
Humans
Illicit Drugs urine
Interleukin-1 Receptor-Like 1 Protein agonists
Interleukin-1 Receptor-Like 1 Protein chemistry
Male
Middle Aged
Retrospective Studies
Risk
Safety-net Providers
San Francisco epidemiology
Severity of Illness Index
Solubility
Substance Abuse Detection
Toxicokinetics
Asymptomatic Diseases epidemiology
Cocaine toxicity
Cocaine-Related Disorders blood
Heart Diseases etiology
Illicit Drugs toxicity
Interleukin-1 Receptor-Like 1 Protein blood
Up-Regulation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2933
- Volume :
- 50
- Issue :
- 13-14
- Database :
- MEDLINE
- Journal :
- Clinical biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28442257
- Full Text :
- https://doi.org/10.1016/j.clinbiochem.2017.04.015