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Acquired hemophilia A: a review of recent data and new therapeutic options.
- Source :
-
Hematology (Amsterdam, Netherlands) [Hematology] 2017 Oct; Vol. 22 (9), pp. 514-520. Date of Electronic Publication: 2017 Apr 25. - Publication Year :
- 2017
-
Abstract
- Objectives: Acquired hemophilia A (AHA) is a rare, but potentially life-threatening, bleeding disorder caused by an autoantibody against factor VIII that interferes with its coagulant function.<br />Methods: We performed a narrative review focusing on the diagnostic aspects of AHA and on the current treatment strategies with particular regard to new data and therapeutic developments.<br />Results: The management of this severe hemorrhagic disorder is based on the control of bleeding with the use of bypassing agents and on the utilization of a variety of immunosuppressant agents with the goal of eliminating the autoantibody permanently.<br />Conclusion: The optimal management of AHA should be multidisciplinary and requires a close collaboration between physicians from various specialties.
- Subjects :
- Algorithms
Autoantibodies immunology
Blood Coagulation Tests
Disease Management
Factor VIII immunology
Hemophilia A etiology
Hemorrhage etiology
Hemorrhage therapy
Hemostatics therapeutic use
Humans
Immunoglobulins, Intravenous therapeutic use
Immunosuppressive Agents therapeutic use
Hemophilia A diagnosis
Hemophilia A therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1607-8454
- Volume :
- 22
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Hematology (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 28441921
- Full Text :
- https://doi.org/10.1080/10245332.2017.1319115