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Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Jun 27; Vol. 61 (7). Date of Electronic Publication: 2017 Jun 27 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.<br /> (Copyright © 2017 American Society for Microbiology.)
- Subjects :
- Administration, Topical
Animals
Antifungal Agents administration & dosage
Antifungal Agents therapeutic use
Cattle
Hoof and Claw microbiology
Humans
Miconazole administration & dosage
Miconazole therapeutic use
Onychomycosis microbiology
Antifungal Agents pharmacokinetics
Miconazole pharmacokinetics
Nails microbiology
Onychomycosis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 61
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 28438926
- Full Text :
- https://doi.org/10.1128/AAC.02554-16